Yue-Mei Zhang

Expertise
Pharmaceutical Drug Discovery Experience: Medicinal Chemistry, Organic Chemistry (Traditional Synthetic and Combinatorial Chemistry).

Education
North Carolina State University, Ph.D. Organic Chemistry.
East China University of Science and Technology, M.S. Fine Chemicals.
East China University of Science and Technology, B.S. Fine Chemicals.

Honors and Societies
Dow Fund Chemistry Fellowship (1988).
Burroughs Wellcome Fund Synthetic Organic Chemistry Fellowship (1994-1995).
Phi Lambda Upsilon (Chemistry National Honorary Society).
American Chemical Society - Organic Division and Medicinal Chemistry Division.

Publications & Presentations
“Synthesis of Pyrimido[4,5-b]indoles and Benzo[4,5-b]furan[2,3-d]pyrimidines via Palladium-catalyzed Intramolecular Arylation” Zhang, Yue-Mei; Razler, Thomas; Paul F Jackson. Tetrahedron Lett. 2002, 43(46), 8235-8239.

“Enantiopure N-acyldihydropyridones as synthetic intermediates: asymmetric synthesis of benzomorphans.” Comins, Daniel L.; Zhang, Yue-mei; Joseph, Sajan P. Org. Lett. 1999, 1(4), 657-59.

“Photochemical reactions of chiral 2,3-dihydro-4(1H)-pyridones: asymmetric synthesis of (-)-perhydrohistrionicotoxin.” Comins, Daniel L.; Zhang, Yue-mei; Zheng, Xiaoling J. Chem. Soc. Chem. Commun. 1998, 22, 2509-2510.

Comins, D. L.; Joseph, S. P.; Hong, H.; Al-awar, R. S.; Foti, C. J.; Zhang, Yue-mei.; Chen, X.; Lamunyon, D. H.; Guerra-Weltzien, M. "Asymmetric Synthesis and Synthetic Utility of 2,3-Dihydro-4-pyridones" Pure & Appl. Chem. 1997, 69, 477

Comins, D. L.; Zhang, Yue-mei. "Anionic Cyclizations of Chiral 2,3-Dihydro-4-pyridones: A Five-Step, Asymmetric Synthesis of Indolizidine 209D" J. Am. Chem. Soc. 1996, 118, 12248.

Comins, D. L.; Joseph, S. P.; Zhang, Yue-mei. "Regio- and Stereoselective Intramolecular Heck Reactions of N-Acyl-2,3-dihydro-4-pyridones" Tetrahedron Lett. 1996, 37, 793.

Zhuang, F.; Bao, Jiankang; Dai, Muzhang; Zhang, Yuemei. “Study on Synthetic Mixed Pigments of Lithol Rubine” Huadong Huagong Xueyuan Xuebao, 1993, 19, 185.

Y. Zhang; T. Razler; P. L. Jackson. Postered at Gorden Research Conference at Heterocyclic Compounds, New Port, RI, 2002. Title: Synthesis of pyrimido[4,5-]furo[2,3-d]pyrimidines via Palladium-catalyzed intramolecular arylation.

Y. Zhang; K. Lackey; S. Cockerill; D. Vanderwall. Postered at Gorden Research Conference at Cancer, New Port, RI, 2000. Title: Potent EGFR/ErbB2 Kinases Inhibitors.

Y. Zhang, D.L.Comins; S. Joseph; postered at National Conference of American Chemical Society, New Orleans, LA. 1999. Title: Asymmetric Synthesis of Benzomorphan Derivatives via 2,3-Dihydropyridones.

D. L. Comins; S. Joseph; Y. Zhang, presented at 109th North Carolina Section Conference of American Chemical Society, Chapel Hill, NC. Title: Regio- and Stereoselectivity of Heck Reactions and Anionic Cyclizations of 2,3-Dihydro-4-pyridones.